Symbol
Name
ID

Bcl2
B cell leukemia/lymphoma 2
MGI:88138

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Acute myeloid leukemia	Non-Hodgkin lymphoma	B-cell lymphoma
Disease(s) Associated with BCL2	Acute myeloid leukemia	Non-Hodgkin lymphoma	B-cell lymphoma
acute myeloid leukemia
follicular lymphoma

Mouse Phenotypes

increased B cell apoptosis

increased T cell apoptosis

increased macrophage apoptosis

increased splenocyte apoptosis

decreased B cell proliferation

abnormal thymus morphology

small thymus

thymus atrophy

decreased thymocyte number

abnormal thymus involution

enlarged spleen

abnormal leukopoiesis

abnormal B cell differentiation

decreased immature B cell number

increased immature B cell number

abnormal T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

decreased mature B cell number

increased mature B cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased pre-B cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased lymphocyte cell number

abnormal lymphocyte morphology

abnormal CD4-positive, alpha beta T cell morphology

abnormal CD8-positive, alpha beta T cell morphology

abnormal spleen morphology

abnormal spleen red pulp morphology

decreased spleen weight

small spleen

spleen atrophy

abnormal spleen white pulp morphology

decreased spleen white pulp amount

abnormal lymphocyte physiology

abnormal B cell physiology

abnormal B cell activation

abnormal T cell physiology

Availability

Mouse Genotype

Bcl2^tm1Dlo/Bcl2^tm1Dlo

Bcl2^tm1Lbox/Bcl2^tm1Lbox

Bcl2^tm1Sjk/Bcl2^tm1Sjk

Bcl2^tm1Tsu/Bcl2^tm1Tsu

Bcl2^tm2.1Lbox/Bcl2^tm2.1Lbox

Bcl2^tm2.1Lbox/Bcl2⁺

Bcl2^tm1Irt/Bcl2^tm1Irt
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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